Joe Odom is NOT holding back!

In a new interview, Lamar Odom's father told Radar Online how he REALLY feels about his ex daughter-in-law, Khloé Kardashian — and her famous family will be far from pleased with what he had to say.

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khloe kardashian and lamar odom (getty images)

"She was a piece of work, man. Khloé was no good for him and he's better off without her! She got my son into a lot of s–t," he told the publication. "Lamar's life and his career went downhill as soon as he got involved with her. He just didn't need all that drama in his life."

Joe, who In Touch previously reported was sick in the hospital, added, "His career suffered as a result and he lost some good years. He just didn't need all that. She stopped his job."

khloe kardashian and lamar odom

Khloé and Lamar wed in 2009 after only one month of dating. She filed for divorce in 2013 based on alleged infidelity and substance abuse on his part. The reality star revoked her request at the end of last year, when Lamar suffered a nearly-fatal drug overdose. She refiled in May.

"Lamar can get on the good foot now. It's a shame he has had to go through all that he has just to get to this point," Joe said.

Relive Lamar's best moments with the Kardashians in the gallery!