It's been six years since Casey Anthony was found not guilty of murdering her daughter, Caylee — and after years of hiding, the disgraced mother returned to the spotlight in 2017 for a three-part Investigation Discovery series called Casey Anthony: An American Murder Mystery.

Now a new report claims that her parents, Cindy and George Anthony, are really not taking this well — and filming took quite a toll on her estranged mother.

MORE: Find out What Amanda Knox Is up to in 2017

“She had three panic attacks. There were paramedics on set. We talked to her for over a week — from the beginning of the case to the end, reliving when she was told Casey was pregnant — and the whole thing brought on these panic attacks,” a source told Page Six.

george and cindy anthony getty images

It's been years since Casey has had a relationship with her parents and she previously accused her father of molesting her. They each opened up about losing their granddaughter during the series.

“It was horrible,” Cindy recalled. “I felt like someone had punched me in the gut and taken every breath from out of my body, and my heart was just being ripped apart. All of our prayers and all of our hopes were gone.”

MORE: See Elizabeth Smart's Hero Sister Mary Katherine Today

George agreed, adding, “The reality hits you like a brick wall you run into, or just having every part of your body being pulled and mangled.”

cindy anthony caylee anthony getty images

Fortunately, the tragedy did not shake Caylee's grandparents' relationship.

“George and Cindy have very different opinions about what happened, but they’re still making it work. They are still married, living in the same house. They often babysit their grandchildren from their son," the same insider told the outlet.

MORE: Enter Here for Your Chance to Win a Fender Guitar

Last month Casey spoke out about the trial in her first public interview since being acquitted.

“I don’t give a s–t about what anyone thinks about me, I never will,” she said. “I’m OK with myself, I sleep pretty good at night.”