Young Stars With MS: Christina Applegate and More Celebrities Battling Multiple Sclerosis

Christina Applegate

In August 2021, Christina Applegate confirmed her MS diagnosis. She was 50 years old at the time.

While she admitted in 2023 that she will likely never act again because of the disease, she said she plans to focus on her podcast and voiceover work to continue her career in the entertainment industry.

Jamie-Lynn Sigler

The actress was diagnosed with MS at age 20 when she was starring on The Sopranos. She’s now cohosting the new “MeSsy” podcast with Christina.

Jack Osbourne

Jack — the son of rocker Ozzy Osbourne, who has Parkinson’s disease, and talk show host Sharon Osbourne, a cancer survivor — was diagnosed with MS at the age of 26.

Selma Blair

In 2022, the Cruel Intentions and Legally Blonde star — who discovered in 2018 she had MS — competed on Dancing With the Stars and released a memoir, Mean Baby. She was in her late 40s when she got her diagnosis.

Emma Caulfield

The Buffy the Vampire Slayer and WandaVision actress has said she hid her MS diagnosis, which came in 2010, for 12 years for fear of losing roles.