Ouch!

Comedian and Jennifer Aniston bestie Chelsea Handler wasted no time throwing major shade at Angelina Jolie on Thursday’s episode of Watch What Happens Live with Andy Cohen.

EXCLUSIVE: Angelina Jolie Has a New Boyfriend!

chelsea handler jennifer aniston

When the 42-year-old was asked what she would do if she was stuck in an elevator with the recently separated mother-of-six, Chels was truly honest with her response.

"I would just look up,” the late night host said. “Exactly what people do in elevators. You know when you fake look at the number because you don’t want to make eye contact. That would be exactly the elevator ride. And then I’d go, ‘Heyyy’ as I walked out. ‘Hey you.’”

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This dig comes after a long-standing feud between the two, which Chelsea mentioned on an episode of her talk show back when Angie was first going through her divorce from Brad Pitt.

“There are reports that part of the problem was Brad was allegedly drinking and smoking too much weed,” Chelsea said. “I wonder why he needed to self-medicate. Maybe because he could have been spending the last 12 years at Lake Como hanging out with George Clooney and Matt Damon, instead of being stuck in a house with 85 kids speaking 15 different languages? Oh yeah, because he married a f–king lunatic. That’s why.”

Though Chels has said that Jennifer doesn’t care about her ex's divorce, it’s clear that she’s picking sides!

“I don’t think Jen cares about what’s going on, and it’s crazy that people think she does," Chelsea told You magazine. “As if she’s sitting around caring about [Angelina]. I know I don’t."

This feud is definitely not going to end any time soon…

Scroll through the gallery below for a timeline of Brad and Angie’s relationship!