Looks like JAY-Z and Kanye West will no longer be running any towns together any time in the near future!

The two — who were once the closest of friends and collaborators — have been feuding on and off for years, but now an insider exclusively tells In Touch that their drama is beyond the point of repair, and will likely never reconcile.

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“They will never speak again,” the insider says. “It’s over.”

Jay made his feelings about his former bestie known on his new album, 4:44, in the track “Kill Jay Z” when he rapped, “But this ‘f–k everybody’ attitude ain’t natural/But you ain’t the same, this ain’t KumbaYe/But you got hurt because you did cool by ‘Ye/You gave him 20 million without blinkin/He gave you 20 minutes on stage, f–k was he thinkin’?/‘F–k wrong with everybody?’ is what you sayin’/But if everybody’s crazy, you’re the one that’s insane.”

The two had long been rumored to be feuding before Jay, 47, name dropped Ye, 40, in a powerful verse — and it has been reported that the “99 Problems” rapper reached his breaking point when Kanye ranted against his wife, Beyoncé, while in concert just days before he was checked into a hospital, allegedly because he was experiencing psychosis.

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“Beyoncé, I was hurt ‘cause I heard you said you wouldn’t be perform unless you won Video of the Year over me and over ‘Hotline Bling,’’’ he said while on stage. “Now, don’t go trying to diss Beyoncé, she is great. Taylor Swift is great. We are all great people. We are all equal. But sometimes we be playing the politics too much and forgetting who we are just to win.”

Shortly after JAY-Z released the track calling his former pal “insane,” the “New Slaves” rapper decided to pull his music from Jay’s streaming service, TIDAL, and void his contract.

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