He was supposed to get the party going at Sunday's MTV European Music Awards in Glasgow, but serious health issues have forced Calvin Harris to drop his scheduled appearance.
On Twitter, he reportedly said "No EMAs for me this weekend. Got some heart problems. Heading home to see if it can be fixed x."
MTV EMA confirmed his cancellation on Facebook, saying "'We have some really sad news." The popular DJ has collaborated with artists such as Ellie Goulding, Big Sean and Florence Welch, and dominated radio stations with hits like "Feel So Close" and "Summer."
The show will be hosted by Nicki Minaj, with performances from Alicia Keys, U2 and Ed Sheeran. Enrique Iglesias, Kiesza and Royal Blood are also scheduled to take the stage.