After two years of Russell Brand running the show, MTV is turning to a female comedian to draw laughs at the 2010 MTV Video Music Awards. Funny woman Chelsea Handler will host the 27th annual live awards program from the Nokia Theater in LA on September 12. “This has been a huge year for hip-hop and rap, and it is well-known that I have the closest ties with these communities - musically and sexually,” the Chelsea Lately hostess, who often features rappers on her E! late night talk show, jokes. Chelsea will be joined on stage by big-name presenters like Justin Bieber, Drake, Ke$ha, Penn Badgley, Trey Songz, Ashley Greene, Selena Gomez and Kanye West, who infamously interrupted Taylor Swift’s acceptance speech for Best Female Video at last year’s show.