The Hairspray star is set to make a guest appearance on his friend's new TV Land show, Kirstie.
The duo were had a previous hit together when they played two characters involved in a romance in the 1989 hit film Look Who’s Talking.
John will begin shooting for the spot sometime early next month, and will play a stagehand on Maddie’s (Kirstie's character's) Broadway play. The pair end up having a one night stand, and though it may have just been a fling for Maddie, John’s character refuses to let her go!
“I'm excited about working with Kirstie again, in addition to such terrific talent on the show. It’s always a treat to be surrounded by people you respect so much both personally and professionally,” the 59-year-old star shared.
The good friends share more than just onscreen love, as they're both known Scientologists! Kirstie is also close friends with John's wife Kelly Preston.
The Cheers actress’ new show will debut on TV Land on Dec. 4, with John’s episode airing sometime later in the season.